PathAI, a leading provider of AI-powered pathology, will give a late-breaker presentation on new results from analytical and clinical validation studies that tested their AIM-NASHTM product and workflow’s accuracy, repeatability, reproducibility, and clinical validity across thousands of samples from several clinical trials, at the European Association for the Study of the Liver’s International Liver Congress 2023 (EASL), which will be held in Vienna, Austria from June 21 to 24, 2023. During EASL, PathAI will also formally launch and release details on its new NASH ExploreTM product.

PathAI’s analytical and clinical validation studies demonstrated that AIM-NASH-assisted pathologist reads of NASH resolution, hepatocellular ballooning, and lobular inflammation were superior to unaided pathologist assessment. Notably, there was a large improvement in scoring accuracy for ballooning and lobular inflammation, which are two of the most challenging components to score and standardize across pathologist reads. These results support PathAI’s vision to develop AI-powered digital pathology solutions to assist pathologists in achieving accurate and reproducible scoring, and complement prior results showing that AI-powered digital pathology is sensitive to drug effect that is not detected by categorical pathologist scoring1 2, while also having the potential to control placebo response rates in NASH clinical trials3.

“The results from these studies inspire confidence in the robustness and value of AIM-NASH, and will pave the way to ultimately adopting AI-assisted NASH scoring as our new gold standard to ensure the greatest confidence in measuring true drug effect in NASH clinical trials,” said Stephen Harrison, M.D., chairman of Summit Clinical Research and a pioneer in the field of liver research and lead author on the study.

At EASL, PathAI is also unveiling NASH Explore, an AI-derived panel of >500 histopathology features that spatially characterize NASH biopsy tissue microarchitecture at the cellular-level from H&E whole-slide images. It characterizes the H&E liver biopsy microenvironment at unprecedented resolution, giving drug developers and clinical researchers the ability to unlock insights that will enable precision drug development in non-alcoholic steatohepatitis (NASH).

“Manual ordinal histologic scoring of fat, inflammation, ballooning and fibrosis from liver biopsies has been the gold standard in NASH assessment for enrollment and therapeutic efficacy, but the NASH community has been pushing for more,” said Andy Beck, M.D., Ph.D., chief executive officer and co-founder of PathAI. “NASH Explore will help uncover new histologic signatures and biomarkers of therapeutic response that could be even more predictive of patient outcomes, and provide more precision in stratifying patients for targeted therapies.”

In response to the NASH community’s request for more sensitive measures of fibrosis that can be seamlessly integrated into existing clinical trial workflows, NASH Explore was developed to not only infer the presence of fibrosis in whole slide images of H&E-stained tissue sections, but also 1) categorize fibrosis into clinically relevant subtypes, and 2) quantify the presence of these fibrosis subtypes in liver lobular zones. By enabling sensitive, specific fibrosis detection from whole slide images (i.e., without requiring proprietary scanning of physical glass slides), NASH Explore allows for rapid and scalable interrogation into patterns of fibrosis that reflect true disease progression and regression.

NASH Explore complements PathAI’s current AIM-NASH product, an AI-powered digital pathology tool that assists pathologists in performing NASH CRN scoring.

DXC Technology (NYSE: DXC), a leading Fortune 500 global technology services company, has forecast five ways software will help create a more sustainable future in the next five years.

"Technology has an outsized role in almost every aspect of sustainability – from increasing productivity, efficiency, and cost savings, to monitoring and modelling progress," said Henrik Hvid Jensen, Chief Technology Strategist, DXC. "As a global IT services leader, DXC sees a number of pivotal ways that technology will help us to drive sustainable development in the next five years."

1. Organizations will adopt circular economy business models

Globally, natural resources are dwindling and their increased exploitation to cater for global demand is having a negative impact on the environment. To build a competitive global circular economy that produces no waste, companies must adapt their business models to maximize resource efficiency, develop recyclable products, and repurpose waste as new offerings.

One of the biggest challenges of moving to a circular economy is collecting and sharing data about a product throughout its entire lifecycle. Digital product passports (DPPs) offer that capability and promise to act as a transparent record of a product's sustainability, environmental and recyclability attributes. The European Union is positioning itself as a first mover in the space and expects most products in the region to be covered by DPP regulation by 2030.

2. AI will help manage natural resources

AI will become increasingly important for tackling most environmental sustainability issues including biodiversity, energy, transportation, and the management of agroecosystems. In the agriculture sector, AI can produce insight and increase automation to improve environmental stewardship and detect diseases and potential infestations before crops or livestock are threatened. Technology not only impacts individual farms' output, but data generates valuable insights that can positively influence policy decisions at the local or national level.

For example, DXC is partnering with the Ministry of Agriculture, Fisheries and Food (MAPA) in Spain to transform the Spanish agricultural sector through data analytics and AI. One project uses AI algorithms to accurately predict forest fires by evaluating environmental data sources collected by MAPA and its partners. Elsewhere, AI helps farmers makes more informed decisions about what crops to plant and where.

3. AI will increase the viability of renewable energy

McKinsey estimates that by 2026, global renewable-electricity capacity will rise more than 80 percent from 2020 levels. For example, Europe will add approximately 36 million renewable-class assets, such as solar panels, electric vehicles (EVs), and energy storage, to the grid in 2025, and 89 million by 2030.

Automation and data analytics can help manage decentralized energy sources, direct excess electricity and flag potential grid weak points before they become significant issues, and help utilities redirect power to where it's needed in real time.

4. There will be a major shift to software-defined EVs in the next decade

The automotive industry accounts for nearly a quarter of global greenhouse emissions and is a major cause of city air pollution. To address this, regulators in the U.S., Europe and elsewhere are reviewing policy and implementing laws to limit the sale of new gas and diesel cars. As a result, eighteen of the world's largest automakers have switched or pledged to switch, either completely or significantly, to EV manufacturing in the coming years.

EVs will be software-defined vehicles (SDVs) with automated capabilities to manage the car more efficiently with particular attention to environmental sensitivities. SDVs feature smart routing and energy optimization that can mitigate issues related to charging capacity and range.

5. Finance systems will be re-engineered to consume less energy

Transitioning to more environmentally sustainable operations is a top priority for banks and financial services organizations. More sustainable software, more efficient algorithms and better data processing are key to these efforts. The global green finance market has thus grown from $5.2 billion in 2012 to more than $540 billion in 2021.

In addition to growing environmentally conscious portfolios, the financial services sector is significantly reducing its energy consumption by enabling efficiencies in data centers. Upgrades include data deduplications and compression which can improve data storage layout and storage efficiency while slashing energy usage. Beyond the traditional financial sector, new approaches are helping to increase the sustainability of the cryptocurrency-mining process.

"We can all look forward to the day when sustainability is the new standard and software will be at the heart of helping us create a climate-secure and competitive future," added Henrik Hvid Jensen, Chief Technology Strategist, DXC.

DXC Technology (NYSE: DXC) helps global companies run their mission-critical systems and operations while modernizing IT, optimizing data architectures, and ensuring security and scalability across public, private and hybrid clouds. The world's largest companies and public sector organizations trust DXC to deploy services to drive new levels of performance, competitiveness, and customer experience across their IT estates. Learn more about how we deliver excellence for our customers and colleagues at DXC.com.

Global technology brand, OPPO's newest Find N2 Flip is designed to enhance the best features of flip phones while eliminating their drawbacks. It features a smaller Flexion Hinge that enables the phone to fold smoothly without leaving a deep crease that can collect dust, making it stand out from other flip phone models. The phone also has the largest cover screen of its kind displaying more features and a battery with higher capacity that charges quickly, offering an enhanced experience and marking a new era in flip phones.

The New Generation Flexion Hinge

OPPO's research and development into folding screen technology dates back to early 2018. In 2020, they unveiled OPPO X 2021, a rollable smartphone that made headlines around the world, as an example of their commitment to pioneering different form factors. They also experimented with countless hinge designs before launching the first Find N with the original Flexion Hinge.

The hinge of a folding phone has a big impact on its features and is a relatively large component. With space always at a premium in smartphone design, less space means less room for other components like batteries. However, the Find N2 Flip's miniaturized hinge ensures that the phone doesn't have to compromise in other areas.

The New Generation Flexion Hinge's structure is built on a solid foundation that goes back almost half a decade and has undergone numerous iterations. It has a simpler, cleaner design and is a more stable solution with fewer parts. The newer hinge features a new cam system and 1/4 spindle assembly, allowing it to hold its form between 45° and 110° when partially folded.

The choice of hinge materials has also been refined, with a flexible stainless steel element that is precision etched, and injected with a soft, pliable material. Aeronautical high-strength steel at the key bearing position ensures the hinge delivers higher reliability, that the tensile strength is up to 15%, and the yield strength is up to 25%. Meanwhile, while aircraft-grade carbon-fiber reinforced polymer ensures strength without adding weight.

The hinge design creates the perfect amount of flex and firmness, whether folding the phone or typing on the display. It also guides the screen into a specific waterdrop fold when the phone is shut, significantly reducing the crease compared to the competition. The waterdrop shape has a larger bending, resulting in a lighter crease and less screen deformation.

Superior Features

The Find N2 Flip's miniaturized hinge enables a larger cover screen and high-capacity, fast-charging battery while enhancing part-folded experiences and durability.

With a 3.26" cover screen, users can easily interact with the Find N2 Flip and access notifications, weather updates, and interactive pet wallpapers without opening the phone.

The Find N2 Flip's innovative hinge mechanism lets users capture clearer selfies with the main camera. But that's not all – the hinge also allows the phone to stand in a part-folded position, giving users the ability to preview content while shooting. The phone is also equipped with Dual Preview, which allows subjects to see a preview of themselves before the photo is taken. And if that's not enough, users can part-fold the phone to unlock FlexForm Mode, which is perfect for time-lapses, video calls and long-exposure photography. With a 4300mAh battery, users can keep the creativity flowing all day long.

The miniaturized hinge doesn't sacrifice durability, with the phone having been tested to withstand 400,000 folds by TÜV Rheinland and extreme temperatures at both -20ºC and 50ºC.

It isn't just the folding mechanism that gives the Find N2 Flip its edge. When shut, the New Generation Flexion Hinge prevents dust and airborne particles from collecting along the crease line, and features the shallowest crease of any folding phone making the screen virtually invisible in most environments.

A New Era in Flip Phones

In summary, thanks to its smaller, New Generation Flexion Hinge, the Find N2 Flip enjoys the largest cover screen, highest capacity battery and fastest charging of any flip phone. It also provides an array of rich cover screen experiences, from interactive wallpapers to useful toggles and widgets, while enhancing photography and durability.

So while the hinge of a flip phone might be a single element, its impact is far-reaching, and thanks to OPPO's game-changing New Generation Flexion Hinge, the Find N2 Flip is a compromise-free breakthrough for the flip phone category.

About OPPO

OPPO is a leading global technology brand since 2004, dedicated to providing products that seamlessly combines art and innovative technology.

OPPO is on a mission to building a multiple-access smart device ecosystem for the era of intelligent connectivity. The smartphone devices have simply been a gateway for OPPO to deliver a diverse portfolio of smart and frontier technologies in hardware, software and system. In 2019, OPPO launched a $7 Billion US Dollar three-year investment plan in R&D to develop core technologies furthering design through technology.

OPPO is firmly pursuing the creation of the best technology products and technological artistry for global users. Based on the brand elements of leading, young and beautiful, OPPO dedicates to the mission of letting the extraordinary users enjoy the beauty of technology.

For the last 10 years, OPPO has focused on manufacturing smartphones with camera capabilities that are second to none. OPPO launched the first mobile phone, the Smile Phone, in 2008, which marked the launch of the brand's epic journey in exploring and pioneering extraordinary technology. Over the years, OPPO has built a tradition of being number one, which became a reality through inventing the world's first rotating camera smartphone way back in 2013, launching the world's then thinnest smartphone in 2014, being the first to introduce 5X Zoom 'Periscope' camera technology and developing the first 5G commercial smartphone in Europe.

Today, OPPO was ranked as the number four smartphone brand globally. OPPO brings the aesthetics of technology of global consumers through the ColorOS system Experience, and Internet service like OPPO Cloud and OPPO+.

OPPO's business covers 60 countries operated by more than 40,000 dedicated employees, with over six research institutes and five R&D centers across the world, from San Francisco to Shenzhen. OPPO also opened an International Design Centre headquartered in London, driving cutting edge technology that will shape the future not only for smartphones but for intelligent connectivity.

HIF Global, the world's leading eFuels company, today announced agreements with Johnson Matthey and Honeywell to conduct preliminary engineering for HIF's first Sustainable Aviation Fuel (SAF) facility in the United States. The facility would produce approximately 11,000 barrels per day of eSAF, decarbonizing over 12 billion air passenger miles per year.

eSAF is sustainable aviation fuel made by combining recycled carbon dioxide (CO2) with hydrogen produced using renewable electricity. eSAF can be dropped-in to existing jet engines without any modifications required.

Meg Gentle, Executive Director of HIF Global, said, "eFuels are a replacement for fossil fuels and are a necessary solution for decarbonizing global transportation. At HIF Global, we have already demonstrated the capability to produce eMethanol for marine transport and eGasoline for road transport with the 2022 start-up of the HIF Haru Oni Demonstration Facility in southern Patagonia, Chile, where the wind is blowing all the time. Together with Johnson Matthey and Honeywell, we intend to deliver an eFuel solution for airplanes before 2030."

Renato Pereira, CEO of HIF USA, added, "Air travel is the most challenging sector of the global transportation infrastructure to decarbonize, with limited low carbon alternatives to serve growing demand for jet fuel. The simplicity of eFuels is that they are produced from air and water for use in existing engines. eSAF produced using Honeywell's technology can reduce CO2 emissions compared to conventional jet fuel by 88%.2 When blended with conventional jet fuel, eSAF can be dropped-in immediately to existing jet engines with no modifications required."

Johnson Matthey's technology will use green hydrogen and recycled CO2 to produce eMethanol which can be used in the shipping and chemical industries or upgraded into other eFuels including eSAF. Johnson Matthey's technology is producing eMethanol today at the HIF Haru Oni Demonstration Plant in Chile.

The Honeywell UOP eFining™ technology processes eMethanol into a light olefin stream utilizing Honeywell's methanol to olefins process, which is then oligomerized, hydrogenated and finally fractionated to produce eSAF. The technology offers a highly integrated design that can process flexible feedstocks using commercially proven processes, resulting in operational reliability, minimized capital expenditures, and low energy intensity.

Alberto Giovanzana, Chief Commercial Officer of Catalyst Technologies at Johnson Matthey, said: "We are very excited to be collaborating again with HIF, offering JM's CO2-to-methanol technology in this leading eFuels project. JM's sustained innovation on methanol process and catalyst technology is allowing us to move at scale and pace in one of the routes to eSAF that enables the transition to net zero."

"As the leader in renewable fuel technology, Honeywell is well aware that creating technologies that can use additional feedstocks is vital to long-term decarbonization of the aviation sector," said Lucian Boldea, president and CEO of Honeywell Performance Materials and Technologies. "The ability to partner with an industry leader like HIF Global to use readily abundant CO2 to produce eSAF is a transformational opportunity for this market."

HIF Global is the world's leading eFuels company, developing projects to convert hydrogen using low cost renewable power into carbon neutral liquid eFuels that can be transported and utilized in existing infrastructure. The name HIF represents the mission of the company: to provide Highly Innovative Fuels to make decarbonization of the planet possible. HIF Chile, HIF USA, HIF Asia Pacific, and HIF EMEA are wholly owned subsidiaries of HIF Global. HIF Global started producing the first liters of synthetic Fuels from the Haru Oni Demonstration Facility in Magallanes, Chile in December 2022 and intends to begin construction of the commercial scale HIF Matagorda eFuels Facility in Texas in 2024. HIF Global's first Australian development, in Tasmania, was announced in July 2022. For more information, visit www.hifglobal.com.

Johnson Matthey is a global leader in sustainable technologies, catalyzing the net zero transition. With over 200 years of sustained commitment to innovation and technological breakthroughs, we improve the performance, function and safety of our customers' products. Our science has a global impact in areas such as low emission transport, energy, chemical processing and making the most efficient use of the planet's natural resources. Today, about 13,000 Johnson Matthey professionals collaborate with our network of customers and partners to make a real difference to the world around us. For more information visit www.matthey.com.

Honeywell delivers industry-specific solutions that include aerospace products and services; control technologies for buildings and industry; and performance materials globally. Our technologies help aircraft, buildings, manufacturing plants, supply chains, and workers become more connected to make our world smarter, safer, and more sustainable. For more news and information on Honeywell, visit https://www.honeywell.com/us/en/news